Derek Chadwick J.

Aluminium in Biology and Medicine

Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known to damage animals and plants via acid rain. Examine... Подробнее

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Acetaldehyde-Related Pathology

Part of the prestigious Novartis Foundation, this is the first book to review the pathology associated with acetaldehyde, a known toxic agent found in cigarette smoke and other pollutants and derived ... Подробнее

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Dental Enamel

The molecular mechanisms and protein species associated with the mineralization of mature dental enamel are active areas of research. This book focuses on specific areas of research including the stru... Подробнее

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Role of the Sarcoplasmic Reticulum in Smooth Muscle

Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to serious pathological conditions, such as hypertensi... Подробнее

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IgE, Mast Cells and the Allergic Response

Reviews recent basic research into IgE, mast cells, and the allergic response and the relevance of this work to human pathophysiology, and discusses new methods of treatment. This symposium is unique ... Подробнее

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Development of the Cardiac Conduction System

The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and... Подробнее

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Neuronal and Cognitive Effects of Oestrogens

Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role.... Подробнее

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Innate Immunity to Pulmonary Infection

Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung. Innate Immunity to Pulmonary Infectio... Подробнее

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Vaccines Against Virally Induced Cancers

An interdisciplinary and multinational group of specialists present contributions describing the current status of vaccines against virally induced tumors and discuss the means by which they can be im... Подробнее

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Neural Transplantation in Neurodegenerative Disease

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches t... Подробнее

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Exploring Brain Functional Anatomy with Positron Tomography

Details the application of positron emission tomography (PET) to the mapping of human cerebral cortical function. Coverage includes all aspects of PET technology. Includes chapters on somatosensory, m... Подробнее

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Alcohol and Cardiovascular Disease

Both timely and topical, this book examines the most important aspects of the relationship between alcohol consumption and health. Drawing together much new and exciting work in this area, it reviews ... Подробнее

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Mast Cells and Basophils

The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to stud... Подробнее

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Steroids and Neuronal Activity

Classical studies of steroid hormones are concerned with their regulation of protein synthesis via the modulation of genomic transcription. But many of the actions of these hormones occur too rapidly ... Подробнее

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Corticotropin-Releasing Factor

Working on Corticotropin-Releasing Factor in a variety of systems, experts present a coherent depiction of this peptide's role in the control and coordination of the response to stress-inducing situat... Подробнее

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The Origins and Consequences of Obesity

This volume examines obesity disorders which can lead to diabetes, hypertension and hyperlipidaemia. It offers an interdisciplinary and international look at all aspects of the origins, consequences a... Подробнее

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Growth Factors and Psychiatric Disorders

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with... Подробнее

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Antibiotic Resistance

Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy, 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in ani... Подробнее

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P2 Purinoceptors

Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregul... Подробнее

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Gramicidin and Related Ion Channel-Forming Peptides

Gramicidin channels have been studied intensively for more than 25 years. They serve as model transport systems for large protein ion channels, since it is difficult to glean high-resolution structura... Подробнее

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Purinergic Signalling in Neuron-Glia Interactions

ATP, the intracellular energy source, is also an extremely important cell–cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry o... Подробнее

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Signalling Pathways in Acute Oxygen Sensing

Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all... Подробнее

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Nuclear Organization in Development and Disease

This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular ... Подробнее

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Mammalian TRP Channels as Molecular Targets

This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mam... Подробнее

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Insect-Plant Interactions and Induced Plant Defence

Insect-Plant Interactions and Induced Plant Defence Chair: John A. Pickett, 1999 This book examines the sophisticated mechanisms that plants use to defend themselves against attack by insects and path... Подробнее

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Molecular Clocks and Light Signalling

The ability at the molecular level to keep track of time is a property shared by organisms ranging from the simplest unicells to humans. The primary feature of these biological clocks is their ability... Подробнее

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The Biosynthesis of the Tetrapyrrole Pigments

Prestigious contributors summarize current knowledge regarding the biosynthesis of tetrapyrrole pigments–chlorophyll, haem, vitamin B12. Describes the structure and regulation of key enzymes along wit... Подробнее

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The Molecular Biology and Pathology of Elastic Tissues

Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and pathology of elastin at the molecular level. Topics includ... Подробнее

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Ethnobotany and the Search for New Drugs

A compilation of articles by prominent experts in their respective fields on compensation for and collaboration with indigenous people in regard to their knowledge and provision of rare plants which a... Подробнее

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Host-Guest Molecular Interactions

Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more sp... Подробнее

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Somatostatin and Its Receptors

This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatost... Подробнее

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Oligonucleotides as Therapeutic Agents

The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRN... Подробнее

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Percept, Decision, Action

Seemingly simple behaviours turn out, on reflection, to be discouragingly complex. For many years, cognitive operations such as sensation, perception, comparing percepts to stored models (short-term a... Подробнее

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Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the e... Подробнее

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Telomeres and Telomerase

Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and functio... Подробнее

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Cancer and Inflammation

Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are ... Подробнее

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Rice Biotechnology

Rice is the most important food crop for half the world's population. Over the last three decades, the imporvement in human nutrition and health in Asia has largely been attributable to a relatively s... Подробнее

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Secondary Metabolites

A comprehensive review of current thinking on the biosynthesis, function and evolution of secondary metabolites in animals, plants and microorganisms. Examines the traditional context of secondary met... Подробнее

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Protein Conformation

How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallograph... Подробнее

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The hERG Cardiac Potassium Channel

This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound bindi... Подробнее

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